PhysSandbox
Classical MechanicsWaves & SoundElectricity & MagnetismOptics & LightGravity & OrbitsLabs
🌙Astronomy & The Sky🌡️Thermodynamics🌍Biophysics, Fluids & Geoscience📐Math Visualization🔧Engineering🧪Chemistry
ENRUESPTFRDE

Related simulators

Similar topics nearby (including related fields) — or browse all 50 in Biophysics, Fluids & Geoscience.

View category →
NewUniversity / research

Michaelis–Menten Kinetics

Launch Simulator

v vs [S] saturation and Lineweaver–Burk line from slope Km/Vmax and intercept 1/Vmax.

NewUniversity / research

Dose-Response & Hill Curves

Launch Simulator

Pharmacologic Hill E(C): EC50/IC50, Hill slope nH, agonist vs antagonist shifts, and therapeutic-window sketch (ED50 vs TD50).

NewUniversity / research

SIR Vaccination Threshold

Launch Simulator

Herd-immunity threshold simulator: R_eff = R0(1-v), SIR outbreak curves, peak infected, and final size vs vaccine coverage.

NewUniversity / research

Chemostat Microbial Growth

Launch Simulator

Continuous culture: Monod μ(S), dilution D, washout threshold, yield, and productivity DX versus D.

NewUniversity / research

Earthquake Aftershocks: Omori + Gutenberg-Richter

Launch Simulator

Modified Omori aftershock decay n(t)=K/(t+c)^p combined with Gutenberg-Richter magnitude-frequency curves, b-value, and a synthetic catalog.

NewSchool

Oxygen-Hemoglobin Dissociation Curve

Launch Simulator

Hill-equation Hb saturation vs pO2 with effective P50 shifts from pH, CO2, and temperature; arterial/venous points, Bohr effect, and O2 content.

PhysSandbox

Interactive physics, chemistry, and engineering simulators for students, teachers, and curious minds.

Physics

  • Classical Mechanics
  • Waves & Sound
  • Electricity & Magnetism

Science

  • Optics & Light
  • Gravity & Orbits
  • Astronomy & The Sky

More

  • Thermodynamics
  • Biophysics, Fluids & Geoscience
  • Math Visualization
  • Engineering
  • Chemistry

© 2026 PhysSandbox. Free interactive science simulators.

PrivacyTermsContact
Home/Biophysics, Fluids & Geoscience/Enzyme Inhibition Kinetics

Enzyme Inhibition Kinetics

Competitive, noncompetitive, and uncompetitive inhibition: Michaelis-Menten curves, apparent Km/Vmax shifts, and a Lineweaver-Burk sketch.

Inhibition mode

Kinetic parameters

1.2
0.45
0.55
0.35
0.7

Measured values

α2.571
v([S] probe)0.452
Apparent Vmax1.200
Apparent Km1.157

The curves are idealized steady-state Michaelis-Menten kinetics. The Lineweaver-Burk panel is useful for seeing which intercept changes under each inhibition mechanism.

Live graphs

About this model

This simulator compares ideal Michaelis-Menten inhibition mechanisms. Competitive inhibition increases apparent Km, noncompetitive inhibition lowers apparent Vmax, and uncompetitive inhibition lowers both Km and Vmax. The same parameters are shown on Michaelis-Menten and Lineweaver-Burk views so the intercept changes are visible.

Who it's for: Biochemistry, pharmacology, enzyme kinetics, and pre-medical biology courses.

Key terms

  • Michaelis-Menten
  • Competitive inhibition
  • Noncompetitive inhibition
  • Uncompetitive inhibition
  • Km
  • Vmax

How it works

Compare competitive, noncompetitive, and uncompetitive enzyme inhibition on Michaelis-Menten and Lineweaver-Burk plots.

Key equations

v = Vmax [S] / (Km + [S]); α = 1 + [I]/Ki
Competitive: Km→αKm; noncompetitive: Vmax→Vmax/α; uncompetitive: Km,Vmax both scale down

Frequently asked questions

Why show Lineweaver-Burk plots?
They are not the best way to fit modern data, but they make changes in slope and intercept visually clear for teaching inhibition mechanisms.
Is this a full enzyme mechanism?
No. It is the steady-state textbook model with a single substrate and reversible inhibitor summarized by Ki.